CD172a


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Specific against	other
Clon	15-414
Applikationen	FC
Menge	0.025 mg
ArtNr	20-783-310573
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-6D2F7F
Specificity:	CD172a
Specificity:	CD172a
Clone:	15-414
Immunogen:	Monocyte-derived dendritic cells.
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the X63-Ag8. 653 myeloma cell line
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 1% Bovine Serum Albumin Suggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6 PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion growth factors or insulin. Mediates negative regulation of phagocytosis mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Subunit:	Binds PTPN11 when tyrosine-phosphorylated except in macrophages where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Ubiquitous. Highly expressed in brain. Detected on myeloid cells but not T-cells. Detected at lower levels in heart placenta lung testis ovary colon liver small intestine prostate spleen kidney skeletal muscle and pancreas.
Ptm:	N-glycosylated.
Ptm:	Phosphorylated on tyrosine residues in response to stimulation with EGF growth hormone insulin and PDGF. Dephosphorylated by PTPN11.
Similarity:	Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Fujioka. Y. et al. (1996) A novel membrane glycoprotein. SHPS-1. that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. 2. van Beek. E. M. et al. (2005) Signal regulatory proteins in the immune system.

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Menge: 0.025 mg

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