MOUSE ANTI BOVINE GFAP

GFAP

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises glial fibrillary acidic protein or GFAP a class III intermediate filament. During development of the central nervous system GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions such as cell structure and movement cell communication and the functioning of the blood-brain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell. Defects in GFAP are a cause of Alexander disease a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation dementia seizures and early death. Clone 1B4 may be used in conjunction with clones 4A11 and 2E1 for increased sensitivity when used in immunohistology. Recommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)