CD44v7/8

CD44v7/8

VFF-17

Tris buffered saline

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA and possibly also through its affinity for other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration tumor growth and progression. Also involved in lymphocyte activation recirculation and homing and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Membrane; Single-pass type I membrane protein.

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.

O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans whose number may affect the accessibility of specific proteinases to their cleavage site(s).

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B) the most frequent allele has Arg-46.