MYELOPEROXIDASE

GWB-DA81E7

4353

2C7

Spleen cells from immunised mice were fused with cells of the mouse X63 AG8-653 myeloma cell line.

Purified IgG prepared by affinity chromatography on Protein G

Flow Cytometry - 1/50 - 1/100Immunohistology - Frozen - 1/1000 - 1/5000Immunohistology - Paraffin - 1/500 - 1/1000Western Blotting - Non-reducing conditions Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq]. 1. Audrain. M. A. P. et al. (1997) Anti-native and recombinant myeloperoxidase monoclonals and human autoantibodies.