p15


ArtNr	20-783-71345
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB, IP, IHC
Clon	DCS-114. 1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D35349
Similar products	20-783-71345
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Genway ID:	GWB-D35349
Specificity:	p15NCBI
Gene ID:	1030
Specificity:	p15
Clone:	DCS-114. 1
Immunogen:	Full length recombinant p15 His tagged
Specificity Note:	This product recognises human p15ink4b a 15kD tumour suppressor protein which inhibits the cyclin D dependent kinases cdk4/6. * N. B. Clone DCS114. 1 co-precipitates cdk4/cdk6.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 08%Sodium Azide Summary: This protein lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This protein is a cyclin-dependent kinase inhibitor which forms a complex with CDK4 or CDK6 and prevents the activation of the CDK kinases thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene which encode distinct proteins have been reported. Summary: This protein lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This protein is a cyclin-dependent kinase inhibitor which forms a complex with CDK4 or CDK6 and prevents the activation of the CDK kinases thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene which encode distinct proteins have been reported. [provided by RefSeq]. 1. Yoon. G. et al. (2002) Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.

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