CD143

GWB-C3803B

CD143

Denatured human kidney CD143 (Angiotensin converting enzyme)

This product recognises human CD143 also known as angiotensin-converting enzyme (ACE). CD143 exists in two forms a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of arterioles and lung capillaries) epithelial cells (especially in proximal renal tubules and in the small intestine) by some neuronal cells and variably on some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Study of CD143 may be relevant to fertility (especially sperm - egg interactions) atherosclerosis and in drug targeting to the lung. This clone has been reported to recognise ACE in Western Blotting. The antibody recognises denatured ACE binding to an epitope in the C domain.

Immunohistology - Paraffin - 1/10 - 1/100Western Blotting - 1/50 - 1/100 1. Metzger. R. et al. (1999) Angiotensin-converting enzyme in non-neoplastic kidney diseases 2. Balyasnikova. I. V. et al. (2003) Monoclonal antibodies to denatured ACE (CD143) broad species specificity. reactivity on paraffin sections and detection of subtle conformational changes in the C-terminal domain of ACE.