CD143

GWB-779A55

CD143

Denatured Human kidney CD143 (angiotensin converting enzyme)

This product recognises human CD143 also know as angiotensin - converting enzyme (ACE). CD143 exists in two forms a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles) epithelial cells (especially in proximal renal tubules and small intestine) by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Study of CD143 may be relevant to fertility (especially sperm-egg interactions) atherosclerosis and in drug targeting to the lung. This clone recognises denatured ACE binding to an epitope in the C domain and has been reported to be active in Western blotting.

Western Blotting - 1/50 - 1/100 1. Metzger. R. et al. (1999) Angiotensin-converting enzyme in non-neoplastic kidney diseases 2. Balyasnikova. I. V. et al. (2003) Monoclonal antibodies to denatured ACE (CD143) broad species specificity. reactivity on paraffin sections and detection of subtle conformational changes in the C-terminal domain of ACE.