CYTOKERATIN 14


ArtNr	20-783-72657
Hersteller	GENWAY
Menge	5 ml
Kategorie	Oncology Antibodies Cell Biology Cytoskeleton Immunohistochemistry Primary Antibodies Intermediate filaments By Organ Breast Cancer
Typ	Antibody
Applikationen	IHC
Clon	LL002
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4DC344
Similar products	20-783-72657
Lieferbar
Genway ID:	GWB-4DC344
Specificity:	CYTOKERATIN 14NCBI
Gene ID:	3861
Specificity:	CYTOKERATIN 14
Clone:	LL002
Immunogen:	Last 15 C-terminal residues of human cytokeratin 14 conjugated to thyroglobulin.
Specificity Note:	This product recognises cytokeratin 14 a type I intermediate filament expressed by stratifying epithelial cells and can be used to distinguish these cell types from simple epithelial cells which do not express cytokeratin 14. Clone LL002 has been reported to be suitable for use in Western blotting. is recommended for this purpose.
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6. 0 is recommended for this purpose. Enzyme digestion is not recommended. Histology: Skin
Preparation:	Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 3
Preservative Stabilisers:		0. 09%Sodium Azide0. 5%Bovine Serum Albumin
Subunit:	Heterotetramer of two type I and two type II keratins. keratin-14 associates with keratin-5. Interacts with TRADD.
Tissue Specificity:	Detected in the basal layer lowered within the more apically located layers specifically in the stratum spinosum stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
Disease:	Defects in KRT14 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering milia formation dystrophic nails and mucous membrane involvement.
Disease:	Defects in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Disease:	Defects in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type althought it is less severe.
Disease:	Defects in KRT14 are the cause of epidermolysis bullosa simplex autosomal recessive (AREBS) [MIM:601001]. AREBS is an intraepidermal epidermolysis bullosa characterized by localized blistering on the dorsal lateral and plantar surfaces of the feet.
Disease:	Defects in KRT14 are the cause of Naegeli-Franceschetti-Jadassohn syndrome (NFJS) [MIM:161000]; also known as Naegeli syndrome. NFJS is a rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints) reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage) palmoplantar keratoderma hypohidrosis with diminished sweat gland function and discomfort provoked by heat nail dystrophy and tooth enamel defects.
Disease:	Defects in KRT14 are the cause of dermatopathia pigmentosa reticularis (DPR) [MIM:125595]. DPR is a rare ectodermal dysplasia characterized by lifelong persistant reticulate hyperpigmentation noncicatricial alopecia and nail dystrophy.
Miscellaneous:	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Similarity:	Belongs to the intermediate filament family. 1. Purkis. P. E. et al. (1990) Antibody markers of basal cells in complex epithelia. 2. Lane. E. B. and Alexander. C. M. (1990) Use of keratin antibodies in tumor diagnosis. 3. Westzels. R. H. W. et al. (1989) Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast. 4. Moll. R. et al. (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia. tumors and cultured cells.

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