ELASTASE


ArtNr	20-783-73216
Hersteller	GENWAY
Menge	0.2 mg
Kategorie	Oncology Antibodies Flow Cytometry Immunohistochemistry ELISA Cardiovascular Research Atherosclerosis Primary Antibodies By Organ Pancreatic Cancer
Typ	Antibody
Applikationen	FC, IHC, ELISA
Clon	39A
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-46F9BD
Similar products	20-783-73216
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Genway ID:	GWB-46F9BD
Specificity:	ELASTASE
Isotype:	IgG1
Clone:	39A
Immunogen:	Elastase from human neutrophils
Specificity Note:	This product is specific for human neutrophil elastase.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:	Phosphate buffered saline pH 7. 2
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1 2 2A 2B 3A and 3B. Elastase 2 hydrolyzes proteins within specialized neutrophil lysosomes called azurophil granules as well as proteins of the extracellular matrix following the protein\' s release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This protein is clustered with other serine protease gene family members azurocidin 1 and proteinase 3 genes at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1 2 2A 2B 3A and 3B. Elastase 2 hydrolyzes proteins within specialized neutrophil lysosomes called azurophil granules as well as proteins of the extracellular matrix following the protein\' s release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This protein is clustered with other serine protease gene family members azurocidin 1 and proteinase 3 genes at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]. 1. Durant. S. et al. (2004) Apoptosis-induced proteinase 3 membrane expression is independent from degranulation.

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Menge: 0.2 mg

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