C8


ArtNr	20-783-74990
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Flow Cytometry Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Applikationen	WB, FC, IHC, ELISA
Clon	056B-373
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3AF335
Similar products	20-783-74990
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Genway ID:	GWB-3AF335
Specificity:	C8NCBI
Gene ID:	733
Specificity:	C8
Clone:	056B-373
Immunogen:	Purified human C8
Specificity Note:	This product recognises complement component 8 (C8) a 151 kDa member of the complement C6/C7/C8/C9 family present in blood serum. C8 is a terminal component of the complement system part of both the complement membrane attack complex (MAC) and important to MAC assembly. C8 binds to the C5b-7 complex anchored to the membrane creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore C8 deficiencies can cause recurring bacterial infections in particular from Neisseria meningitides. Histology: Kidney from post streptoccal glomerulonephritis patients
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Borate buffered saline pH8. 2 - 8. 4
Preservative Stabilisers:		0. 02%Sodium Azide (NaN3)
Function:	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
Subunit:	C8 is composed of three chains: alpha beta and gamma. The alpha and gamma chains are disulfide bonded.
Subcellular Location:	Secreted.
Similarity:	Belongs to the lipocalin family. 1. Rosa. D. (2004) Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis - case report and literature review. 2. Schreck. S. et al. (2000) Human complement protein C8 gamma.

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