CD4

CD4

CT7

Spleen cells from immunised BALB/c mice were fused with cells of the X63. Ag8. 653 mouse myeloma cell line.

Purified IgG prepared by affinity chromatography on Protein G.

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.

Primary receptor for HIV-1.

Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Tan. B. T. G. et al. (1985) Production of monoclonal antibodies defining guinea pig T-cell surface markers and a strain 13 Ia-like antigen. the value of immunohistological screening. 2. Baker. D. et al. (1987) Changes in lymphocyte subsets after treatment with cyclophosphamide and during the development of contact sensitivity in the guinea pig. 3. Liversidge. J. et al. (1988) Experimental autoimmune uveitis (EAU): Immunophenotypic analysis of inflammatory cells in chorio retinal lesions: 4. Steerenburg. P. A. et al. (1991) Tumour rejection after transfer of line-10-immunity is mediated by two T-cell populations. 5. Debout. C. et al. (1991) The Kurloff Cell in estrogenized guinea pigs as a CT7+ 8BE6-CT6-MR-1-CT10-IgM-Lymphocyte with natural killer activity.