Glucagon

GWB-7B59D0

PancreasCellular

Recombinant full length human glucagon protein expressed in E. Coli. Glucagon exerts rapid and delayed effects on the liver whereby it provokes a coordinated cAMP-and Ca2+-dependent increase in glycogenolysis glycolysis glucose cycling gluconeogenesis and ketogenesis. Glucagon also stimulates hepatic proteolysis in lysosomes and inhibits protein synthesis so that glucogenic amino acids contribute easily to gluconeogenesis. Immunocytochemical studies have revealed the presence of glucagons in the alpha cells of the pancreastic islets. Glucagon is found in other normal tissues such as small intestine and stomach.