MOUSE ANTI RAT CD80

CD80

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD80 otherwise known as B7-1 a type I transmembrane glycoprotein and member of the Ig superfamily which acts as a ligand for both CD28 and CD152 (CTLA-4) and is primarily expressed on antigen presenting cells (APCs) including dendritic cells. CD80 is a B cell activation antigen which functions in the CD28-CD80/CD86 co-stimulatory pathway vital for T cell activation and proliferation. In contrast the interaction of CD80 with CD152 has an inhibitory effect on T cell responses. Clone 3H5 has been shown to block the co-stimulatory activity of rat CD80. Recommended for functional studies. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)