MOUSE ANTI RAT CD86:FITC

CD86

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD86 otherwise known as B7-2 a type I transmembrane protein and member of the Ig superfamily which acts as a ligand for both CD28 and CD152 (CTLA-4) and is primarily expressed on antigen presenting cells (APCs) including dendritic cells and also on germinal centre B cells and macrophages. Like CD80 CD86 is an accessory molecule which functions in the CD28-CD80/CD86 co-stimulatory pathway vital for T cell activation crosstalk between T and B cells and Th2-mediated Ig production. Clone 24F has been shown to block the co-stimulatory activity of rat CD86. AbD Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC