MOUSE ANTI RAT CD49d

CD49d

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD49d otherwise known as integrin alpha 4 chain/VLA-4 a 150kDa type-1 transmembrane glycoprotein and member of the integrin alpha chain family which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes monocytes thymocytes mast cells and dendritic cells and is involved in cell-cell interactions mononuclear cell trafficking to sites of endothelial inflammation and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitro and in vivo functions of CD49d(1). Studies have shown that in rat Peyer\' s patches clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV) and significantly inhibits the transendothelial migration of T lymphocytes(2). Recommended for functional studies. Recommended Negative Controls: MOUSE IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGHuCAL Anti Mouse IgG2aRabbit Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L) 1. Singer C. F. et al. (2004) Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: Free IGF-II is correlated with breast cancer size. Clin. Can. Res. 10: 4003-4009. [1] \" Sequence of cDNA encoding human insulin-like growth factor I precursor. \" Jansen M. van Schaik F. M. A. Ricker A. T. Bullock B. Woods D. E. Gabbay K. H. Nussbaum A. L. Sussenbach J. S. van den Brande J. L. Nature 306:609-611(1983) [PubMed: 6358902] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [2] \" Organization of the human genes for insulin-like growth factors I and II. \" de Pagter-Holthuizen P. van Schaik F. M. A. Verduijn G. M. van Ommen G. J. B. Bouma B. N. Jansen M. Sussenbach J. S. FEBS Lett. 195:179-184(1986) [PubMed: 3002851] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] \" Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library. \" le Bouc Y. Dreyer D. Jaeger F. Binoux M. Sondermeyer P. FEBS Lett. 196:108-112(1986) [PubMed: 2935423] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [4] \" Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides. \" Rotwein P. Pollock K. M. Didier D. K. Krivi G. G. J. Biol. Chem. 261:4828-4832(1986) [PubMed: 2937782] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [5] \" Two insulin-like growth factor I messenger RNAs are expressed in human liver. \" Rotwein P. Proc. Natl. Acad. Sci. U. S. A. 83:77-81(1986) [PubMed: 3455760] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [6] \" Complete nucleotide sequence of the high molecular weight human IGF-I mRNA. \" Steenbergh P. H. Koonen-Reemst A. M. C. B. Cleutjens C. B. J. M. Sussenbach J. S. Biochem. Biophys. Res. Commun. 175:507-514(1991) [PubMed: 2018498] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Liver. [7] \" Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain. \" Sandberg-Nordqvist A. -C. Staehlbom P. -A. Lake M. Sara V. R. Brain Res. Mol. Brain Res. 12:275-277(1992) [PubMed: 1372070] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain. [8] \" Characterization of insulin-like growth factor 1 in human primary brain tumors. \" Sandberg-Nordqvist A. -C. Staehlbom P. -A. Reinecke M. Collins V. P. von Holst H. Sara V. Cancer Res. 53:2475-2478(1993) [PubMed: 8495408] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. [9] NIEHS SNPs programSubmitted (MAR-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [10] \" The finished DNA sequence of human chromosome 12. \" Scherer S. E. Muzny D. M. Buhay C. J. Chen R. Cree A. Ding Y. Dugan-Rocha S. Gill R. Gunaratne P. Harris R. A. Hawes A. C. Hernandez J. Hodgson A. V. Hume J. Jackson A. Khan Z. M. Kovar-Smith C. Lewis L. R. Lozado R. J. Metzker M. L. Milosavljevic A. Miner G. R. Montgomery K. T. Morgan M. B. Nazareth L. V. Scott G. Sodergren E. Song X. -Z. Steffen D. Lovering R. C. Wheeler D. A. Worley K. C. Yuan Y. Zhang Z. Adams C. Q. Ansari-Lari M. A. Ayele M. Brown M. J. Chen G. Chen Z. Clerc-Blankenburg K. P. Davis C. Delgado O. Dinh H. H. Draper H. Gonzalez-Garay M. L. Havlak P. Jackson L. R. Jacob L. S. Kelly S. H. Li L. Li Z. Liu J. Liu W. Lu J. Maheshwari M. Nguyen B. -V. Okwuonu G. O. Pasternak S. Perez L. M. Plopper F. J. H. Santibanez J. Shen H. Tabor P. E. Verduzco D. Waldron L. Wang Q. Williams G. A. Zhang J. Zhou J. Allen C. C. Amin A. G. Anyalebechi V. Bailey M. Barbaria J. A. Bimage K. E. Bryant N. P. Burch P. E. Burkett C. E. Burrell K. L. Calderon E. Cardenas V. Carter K. Casias K. Cavazos I. Cavazos S. R. Ceasar H. Chacko J. Chan S. N. Chavez D. Christopoulos C. Chu J. Cockrell R. Cox C. D. Dang M. Dathorne S. R. David R. Davis C. M. Davy-Carroll L. Deshazo D. R. Donlin J. E. D\' Souza L. Eaves K. A. Egan A. Emery-Cohen A. J. Escotto M. Flagg N. Forbes L. D. Gabisi A. M. Garza M. Hamilton C. Henderson N. Hernandez O. Hines S. Hogues M. E. Huang M. Idlebird D. G. Johnson R. Jolivet A. Jones S. Kagan R. King L. M. Leal B. Lebow H. Lee S. LeVan J. M. Lewis L. C. London P. Lorensuhewa L. M. Loulseged H. Lovett D. A. Lucier A. Lucier R. L. Ma J. Madu R. C. Mapua P. Martindale A. D. Martinez E. Massey E. Mawhiney S. Meador M. G. Mendez S. Mercado C. Mercado I. C. Merritt C. E. Miner Z. L. Minja E. Mitchell T. Mohabbat F. Mohabbat K. Montgomery B. Moore N. Morris S. Munidasa M. Ngo R. N. Nguyen N. B. Nickerson E. Nwaokelemeh O. O. Nwokenkwo S. Obregon M. Oguh M. Oragunye N. Oviedo R. J. Parish B. J. Parker D. N. Parrish J. Parks K. L. Paul H. A. Payton B. A. Perez A. Perrin W. Pickens A. Primus E. L. Pu L. -L. Puazo M. Quiles M. M. Quiroz J. B. Rabata D. Reeves K. Ruiz S. J. Shao H. Sisson I. Sonaike T. Sorelle R. P. Sutton A. E. Svatek A. F. Svetz L. A. Tamerisa K. S. Taylor T. R. Teague B. Thomas N. Thorn R. D. Trejos Z. Y. Trevino B. K. Ukegbu O. N. Urban J. B. Vasquez L. I. Vera V. A. Villasana D. M. Wang L. Ward-Moore S. Warren J. T. Wei X. White F. Williamson A. L. Wleczyk R. Wooden H. S. Wooden S. H. Yen J. Yoon L. Yoon V. Zorrilla S. E. Nelson D. Kucherlapati R. Weinstock G. Gibbs R. A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].