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Sheep anti Rabbit Fibrinogen

Sheep anti Rabbit Fibrinogen

ArtNr	18-511-245453
Hersteller	GENWAY
Menge	1 mg
Kategorie	Antibodies Cell Biology Cell Movement Cell Adhesion ELISA Primary Antibodies
Typ	Antibody
Applikationen	ELISA
Specific against	Rabbit (Oryctolagus cuniculus)
Host	Sheep
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-60E80C
Similar products	18-511-245453
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Genway ID:	GWB-60E80C
Host Animal:	Sheep
Immunogen:	Rabbit fibrinogen
Specificity:	Fibrinogen
Specificity:	Rabbit fibrinogen
Type of Product:	Polyclonal Antibodies to Platelets and Hemostasis Antigens
Concentration:	Lot specific (OD280nm E0. 1% = 1. 36)
Buffer:	10mM HEPES pH 7. 4 containing 0. 15M Sodium chloride 50% glycerolApplications Notes : Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Sheep anti Rabbit Fibrinogen. Sheep Antibody to Rabbit Fibrinogen
Function:	Fibrinogen has a double
Function:	yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
Subunit:	Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
Subcellular Location:	Secreted.
Domain:	A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back contributing a fourth strand to the coiled coil structure.
Ptm:	The alpha chain is not glycosylated.
Ptm:	Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue forming fibronectin-fibrinogen heteropolymers.
Ptm:	About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Ptm:	Conversion of fibrinogen to fibrin is triggered by thrombin which cleaves fibrinopeptides A and B from alpha and beta chains and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Disease:	Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations.
Disease:	Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Disease:	Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1 fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome arterial hypertension hepatosplenomegaly cholestasis petechial skin rash.
Similarity:	Contains 1 fibrinogen C-terminal domain.

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Menge: 1 mg

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