Human NPR-B (a.a. 288-302) Peptide

GWB-C48671

Purified Cardiac Markers

Not applicable.

Receptor for atrial natriuretic peptide (ANP) brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP & gt; BNP & gt; ANP.

Membrane; Single-pass type I membrane protein.

Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 protein kinase domain.