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Stathmin 1 (Phospho-Ser15) Antibody Blocking Peptide

Stathmin 1 (Phospho-Ser15) Antibody Blocking Peptide

ArtNr	06-785-213180
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Peptides By Organ Bone Cancer
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-4A0FDD
Similar products	06-785-213180
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Genway ID:	GWB-4A0FDD
Function:	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Subunit:	Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Ubiquitous. Expression is strongest in fetal and adult brain spinal cord and cerebellum followed by thymus bone marrow testis and fetal liver. Expression is intermediate in colon ovary placenta uterus and trachea and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver.
Ptm:	Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
Disease:	Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes non-leukemic proliferating lymphoid cells bone marrow cells or cells from patients with chronic lymphoid or myeloid leukemia.
Similarity:	Belongs to the stathmin family.

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Menge: 0.1 mg

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