GTF2H1 (general transcription factor IIH. polypeptide 1. 62kDa)

GWB-BDE24F

1:1562500

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and when complexed to CAK in RNA transcription by RNA polymerase II.

Nucleus.

Contains 2 BSD domains. [1] Bethke L. Murray A. Webb E. Schoemaker M. Muir K. McKinney P. Hepworth S. Dimitropoulou P. Lophatananon A. Feychting M. et al. Comprehensive analysis of DNA repair gene variants and risk of meningioma[2] Di Lello P. Nguyen B. D. Jones T. N. Potempa K. Kobor M. S. Legault P. and Omichinski J. G. NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites[3] Liu Y. Ando S. Xia X. Yao R. Kim M. Fondell J. and Yen P. M. et al. p62 A TFIIH subunit directly interacts with thyroid hormone receptor and enhances T3-mediated transcription[4] Giglia-Mari G. Coin F. Ranish J. A. Hoogstraten D. Theil A. Wijgers N. Jaspers N. G. Raams A. Argentini M. van der et al. A new tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A[5] Zhou M. Deng L. Kashanchi F. Brady J. N. Shatkin A. J. and Kumar A. The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA[6] Fischer L. Gerard M. Chalut C. Lutz Y. Humbert S. Kanno M. Chambon P. Egly J. -M. Cloning of the 62-kilodalton component of basic transcription factor BTF2. [7] Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. et al. Complete sequencing and characterization of 21 243 full-length human cDNAs. [8] Rieder M. J. Livingston R. J. Daniels M. R. Montoya M. A. Chung M. -W. Miyamoto K. E. Nguyen C. P. Nguyen D. A. Poel C. L. Robertson P. D. et al. NIEHS-SNPs environmental genome project NIEHS ES15478 Department of Genome Sciences Seattle WA (URL: http://egp. gs. washington. edu). [9] Critcher R. Palin A. H. Zhang J. Chin S. F. Gayther S. A. Li L. Cohen S. N. Caldas C. Farr C. J. An aphidicolin-sensitive fragile site (FRA11C) lies within 100 kb of the putative tumour suppressor gene TSG101 on both human and mouse chromosomes. [10] Liu J. He L. Collins I. Ge H. Libutti D. Li J. Egly J. -M. Levens D. The FBP interacting repressor targets TFIIH to inhibit activated transcription.