Neuropeptide EI NH2

ArtNr	18-272-195352
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Food Safety Allergenes Peptides & Proteins Immunohistochemistry Peptides By Organ Brain Cancer
Typ	Peptides
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-A33D49
Similar products	18-272-195352
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Genway ID:	GWB-A33D49
Isotype:	IgG
Immunogen:	NEI-NH2: Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2 (rat)
Antigen Species:	Rat
Specificity:	This antibody recognises neuropeptide E (Glu) I(Ile)-NH2 (NE1 NH2) which is located in the melanin-concentrating hormone (MCH precursor and is co-synthesized with MCH Cells.
Target:	Neuropeptide EI NH2 Storage
Preservative:	0. 09% Sodium Azide. Constituents: PBS containing 0. 3% Triton. Whole serum is supplied diluted.
Application Note:	IHC-Fr: Use at a dilution of 1/200 - 1/2000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Function:	MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior such as food intake and general arousal. May also have a role in spermatocyte differentiation.
Subcellular Location:	Secreted.
Tissue Specificity:	Predominantly expressed in lateral hypothalamus also detected in pallidum neocortex and cerebellum. Also found in thymus brown adipose tissue duodenum and testis (spermatogonia early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product encompassing the NEI and MCH domains of the precursor is found predominantly.
Ptm:	Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide NGE may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3 PC2 and PC5/6.
Similarity:	Belongs to the melanin-concentrating hormone family.

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