Glucagon-like peptide 2 receptor

GWB-F8B14D

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Belongs to the G-protein coupled receptor 2 family [view classification]. Summary: The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [1] Sams A. Hastrup S. Andersen M. and Thim L. et al. Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines[2] Guan X. Karpen H. E. Stephens J. Bukowski J. T. Niu S. Zhang G. Stoll B. Finegold M. J. Holst J. J. Hadsell D. Nichols B. L. and et al. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow[3] Estall J. L. Koehler J. A. Yusta B. and Drucker D. J. et al. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization endocytosis and G-protein-dependent effector activation[4] Koehler J. A. Yusta B. and Drucker D. J. et al. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways[5] Orskov C. Hartmann B. Poulsen S. S. Thulesen J. Hare K. J. and Holst J. J. GLP-2 stimulates colonic growth via KGF released by subepithelial myofibroblasts with GLP-2 receptors[6] Munroe D. G. Gupta A. K. Kooshesh F. Vyas T. B. Rizkalla G. Wang H. Demchyshyn L. Yang Z. -H. Kamboj R. K. Chen H. et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.