Fibrinopeptide A

ArtNr	20-511-242127
Hersteller	GENWAY
Menge	1 mg
Kategorie	Oncology Peptides & Proteins ELISA Peptides By Organ Heart & Blood Cancer
Typ	Peptides
Applikationen	ELISA
Clon	26E7
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-405BC1
Similar products	20-511-242127
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Genway ID:	GWB-405BC1
Isotype:	IgG2b
Clone:	26E7Host Animal: Mouse. Hybridization of Sp 2/0 myeloma cells with spleen cells from Balb/c mice.
Immunogen:	Human Fibrinopeptide A. conjugated with a carrier protein.
Specificity:	Fibrinopeptide A region in the alpha-chain of fibrinogen and free fibrinopeptide A.
Type of Product:	Monoclonal Antibodies to Platelets and Hemostasis Antigens
Concentration:	Lot specificPreservatives: 0. 1% Sodium azide
Buffer:	PBS. pH 7. 4Applications Notes : Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. . Recommended pair for detection of fibrinogen in sandwich immunoassay:. Capture. 20-511-242127 Detection. 20-511-242096
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Fibrinopeptide A. Monoclonal Antibody to Fibrinopeptide A
Function:	Fibrinogen has a double
Function:	yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
Subunit:	Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
Subcellular Location:	Secreted.
Domain:	A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back contributing a fourth strand to the coiled coil structure.
Ptm:	The alpha chain is not glycosylated.
Ptm:	Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue forming fibronectin-fibrinogen heteropolymers.
Ptm:	About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Ptm:	Conversion of fibrinogen to fibrin is triggered by thrombin which cleaves fibrinopeptides A and B from alpha and beta chains and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Disease:	Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations.
Disease:	Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Disease:	Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1 fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome arterial hypertension hepatosplenomegaly cholestasis petechial skin rash.
Similarity:	Contains 1 fibrinogen C-terminal domain.

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Menge: 1 mg

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