C-PEPTIDE II

GWB-D3EE40

C-PEPTIDE II

Fragments of rat C-peptide conjugated to a carrier protein.

This product recognises rat C-peptide II. C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats two isoforms of proinsulin exists the difference is two amino acid residues in the C-peptide termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+ K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. This product recognises rat and mouse C-peptide II. It does not recognise rat C-peptide I and reacts very weakly with mouse C-peptide I.

Phosphate buffered saline pH7. 4

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides amino acids and fatty acids. It accelerates glycolysis the pentose phosphate cycle and glycogen synthesis in liver.

Secreted.

Belongs to the insulin family.