RECOMBINANT HUMAN RESISTIN

RESISTIN

10mM Sodium Citrate

Human resistin a disulfide-linked homodimeric protein otherwise known as adipose tissue-specific secretory factor is an adipose-derived hormone and member of the resistin/FIZZ family implicated as a suppressor of the ability of insulin to reduce blood sugar and to play a role in type 2 diabetes and obesity. Studies have shown that resistin is involved in an increase in the transcription/expression of many pro-inflammatory cytokines including interleukin-1 -6 and -12 and also upregulates vascular cell-adhesion molecule-1 (VCAM-1) intracellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1/CCL2). [1] \" A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. \" Waterman M. L. Fischer W. H. Jones K. A. Genes Dev. 5:656-669(1991) [PubMed: 2010090] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) PARTIAL PROTEIN SEQUENCE FUNCTION. [2] \" The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. \" Hovanes K. Li T. W. Waterman M. L. Nucleic Acids Res. 28:1994-2003(2000) [PubMed: 10756202] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] ALTERNATIVE SPLICING. [3] \" New transcript isoform of the human LEF-1 devoid of HMG domain derived from alternative splicing of exon 8. \" Kobielak A. Kobielak K. Trzeciak W. H. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin. [5] \" ALY a context-dependent coactivator of LEF-1 and AML-1 is required for TCRalpha enhancer function. \" Bruhn L. Munnerlyn A. Grosschedl R. Genes Dev. 11:640-653(1997) [PubMed: 9119228] [Abstract]Cited for: INTERACTION WITH THOC4. [6] \" Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse. \" Korinek V. Barker N. Willert K. Molenaar M. Roose J. Wagenaar G. Markman M. Lamers W. Destree O. Clevers H. Mol. Cell. Biol. 18:1248-1256(1998) [PubMed: 9488439] [Abstract]Cited for: INTERACTION WITH CTNNB1. [7] \" Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. \" Levanon D. Goldstein R. E. Bernstein Y. Tang H. Goldenberg D. Stifani S. Paroush Z. Groner Y. Proc. Natl. Acad. Sci. U. S. A. 95:11590-11595(1998) [PubMed: 9751710] [Abstract]Cited for: INTERACTION WITH TLE1 INHIBITION OF TRANSCRIPTIONAL ACTIVATION BY TLE1. [8] \" Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. \" Hovanes K. Li T. W. H. Munguia J. E. Truong T. Milovanovic T. Lawrence Marsh J. Holcombe R. F. Waterman M. L. Nat. Genet. 28:53-57(2001) [PubMed: 11326276] [Abstract]Cited for: IDENTIFICATION (ISOFORM 3) EXPRESSION IN COLON CANCER. [9] \" All Tcf HMG box transcription factors interact with Groucho-related co-repressors. \" Brantjes H. Roose J. van De Wetering M. Clevers H. Nucleic Acids Res. 29:1410-1419(2001) [PubMed: 11266540] [Abstract]Cited for: FUNCTIONAL INTERACTION WITH TLE1; TLE2; TLE3 AND TLE4. [10] \" I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. \" Kusano S. Raab-Traub N. Mol. Cell. Biol. 22:6393-6405(2002) [PubMed: 12192039] [Abstract]Cited for: INTERACTION WITH MDFI AND MDFIC.