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Human Growth Hormone &gt,=70% Pure

Human Growth Hormone &gt,=70% Pure

ArtNr	11-511-248592
Hersteller	GENWAY
Menge	1 mg
Kategorie	Metabolism Diabetes Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-7BDED3
Similar products	11-511-248592
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Genway ID:	GWB-7BDED3
Specificity:	Growth Hormone (hGH) > =70% Pure Human
Type of Product:	Purified Hormones and Steroids
Inactivation:	Not applicable
Buffer:	Lyophilized from 50mM ammonium bicarbonateApplications Notes : Specific methodologies have not been tested using this product.
Concentration:	Activity: 4. 1 U/mg (ELISA) (WHO IRP 88/264 (rhGH) 3U/mg standard) Human Growth Hormone > =70% Pure. . Cross-reactivity:. FSH (w/w) not detected (Bayer ACS:180). LH (w/w) not detected (Bayer ACS:180). hTSH (w/w) not detected (Bayer ACS:180). Prolactin (w/w) not detected (Bayer ACS:180)
Function:	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subunit:	Monomer dimer trimer tetramer and pentamer disulfide-linked or non-covalently associated in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.
Subcellular Location:	Secreted.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which causes short stature.
Disease:	Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type II (IGHD II) [MIM:173100]. IGHD II is an autosomal dominant deficiency of GH which causes short stature.
Disease:	Defects in GH1 may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth. Pharmaceutical: Available under the names Nutropin or Protropin (Genentech) Norditropin (Novo Nordisk) Genotropin (Pharmacia Upjohn) Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner\' s syndrome.
Miscellaneous:	Circulating GH shows a great heterogeneity due to alternative splicing differential post-translational modifications of monomeric forms oligomerization optional binding to 2 different GH-binding proteins and potentially proteolytic processing.
Similarity:	Belongs to the somatotropin/prolactin family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 1 mg

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