RECOMBINANT MOUSE SDF-1 ALPHA

GWB-560A58

Purified recombinant SDF-1 alpha expressed in E. coli

SDF-1 alpha otherwise known as CXCL12a is a stromal cell derived CXC chemokine which together with SDF-1 beta arises from alternative splicing of the SDF-1 gene and acts as a chemoattractant for T and B lymphocytes monocytes and migratory neurons. SDF-1 binds with high-affinity to the G protein-coupled receptor CXCR4 (fusin) and acts as an inhibitor of the CXCR4-mediated entry of HIV-1 virus into target T-cells. 1. Acharya S. et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. P. N. A. S. 93: 13629-13634. [1] \" hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. \" Acharya S. Wilson T. Gradia S. Kane M. F. Guerrette S. Marsischky G. T. Kolodner R. D. Fishel R. Proc. Natl. Acad. Sci. U. S. A. 93:13629-13634(1996) [PubMed: 8942985] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] VARIANT GLU-39. [2] \" Alternative splicing of GTBP in normal human tissues. \" Shiwaku H. O. Wakatsuki S. Mori Y. Fukushige S. Horii A. DNA Res. 4:359-362(1997) [PubMed: 9455487] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] ALTERNATIVE SPLICING. [3] NIEHS SNPs programSubmitted (MAR-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS GLU-39; VAL-396; ALA-623 AND VAL-886. [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. [5] \" GTBP a 160-kilodalton protein essential for mismatch-binding activity in human cells. \" Palombo F. Gallinari P. Iaccarino I. Lettieri T. Hughes M. D\' Arrigo A. Truong O. Hsuan J. J. Jiricny J. Science 268:1912-1914(1995) [PubMed: 7604265] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-1360 PARTIAL PROTEIN SEQUENCE. [6] \" Molecular cloning of the N-terminus of GTBP. \" Nicolaides N. C. Palombo F. Kinzler K. W. Vogelstein B. Jiricny J. Genomics 31:395-397(1996) [PubMed: 8838326] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-116. [7] \" Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. \" Drummond J. T. Li G. -M. Longley M. J. Modrich P. Science 268:1909-1912(1995) [PubMed: 7604264] [Abstract]Cited for: CHARACTERIZATION PARTIAL PROTEIN SEQUENCE. [8] \" Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. \" Blackwell L. J. Martik D. Bjornson K. P. Bjornson E. S. Modrich P. J. Biol. Chem. 273:32055-32062(1998) [PubMed: 9822680] [Abstract]Cited for: FUNCTION. [9] \" DNA-dependent activation of the hMutSalpha ATPase. \" Blackwell L. J. Bjornson K. P. Modrich P. J. Biol. Chem. 273:32049-32054(1998) [PubMed: 9822679] [Abstract]Cited for: FUNCTION. [10] \" hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. \" Iaccarino I. Marra G. Palombo F. Jiricny J. EMBO J. 17:2677-2686(1998) [PubMed: 9564049] [Abstract]Cited for: FUNCTION MUTAGENESIS OF LYS-1140.