FIBRONECTIN


ArtNr	11-783-79452
Hersteller	GENWAY
Menge	1 mg
Kategorie	Oncology Neuroscience Neural Adhesion Molecules By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Western Blot ELISA Cell Stainings ECM
Typ	Proteins
Applikationen	WB, ELISA
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-CC5AF0
Similar products	11-783-79452
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Genway ID:	GWB-CC5AF0
Specificity:	FIBRONECTIN
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		None present Reconstitution: Reconstitute with 4M urea or with CAPS buffer at pH 11. To maintain activity dilute to a neutral pH once dissolved.
Function:	Fibronectins bind cell surfaces and various compounds including collagen fibrin heparin DNA and actin. Fibronectins are involved in cell adhesion cell motility opsonization wound healing and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
Subunit:	Mostly heterodimers or multimers of alternatively spliced variants connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1 AMBP TNR LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity).
Subcellular Location:	Secreted extracellular space extracellular matrix.
Tissue Specificity:	Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms) made by fibroblasts epithelial and other cell types is deposited as fibrils in the extracellular matrix. Ugl-Y1 Ugl-Y2 and Ugl-Y3 are found in urine. Developmental Stage: Ugl-Y1 Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
Ptm:	Sulfated.
Ptm:	It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
Ptm:	Forms covalent cross-links mediated by a transglutaminase such as F13A or TGM2 between a glutamine and the epsilon-amino group of a lysine residue forming homopolymers and heteropolymers (e. g. fibrinogen-fibronectin collagen-fibronectin heteropolymers).
Disease:	Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria microscopic hematuria and hypertension that leads to end-stage renal failure in the second to fifth decade of life.
Similarity:	Contains 12 fibronectin type-I domains.
Similarity:	Contains 2 fibronectin type-II domains.
Similarity:	Contains 16 fibronectin type-III domains.

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Menge: 1 mg

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Lieferung vsl. bis 27.11.2025

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