ELASTASE

ArtNr	11-783-79525
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Peptides & Proteins Recombinant Proteins ELISA Cardiovascular Research Atherosclerosis By Organ Bone Cancer
Typ	Proteins
Applikationen	ELISA
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-7AD2F5
Similar products	11-783-79525
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Genway ID:	GWB-7AD2F5
Specificity:	ELASTASEActivity: 20-22 U/mg protein Activity: 20-22 U/mg proteinShelf Life: 12 months from date of despatch.
Preservative Stabilisers:		None present. Reconstitution: Reconstitute with 50 mM sodium acetate pH 5. 5 150 mM NaCl. Product
Note:	1 unit is defined as the amount of enzyme that hydrolyzes one umole per minute of MeO-Suc-Ala-Ala-Pro-Val-pNA at 25 degree C. in 100mM Tris-Hcl. pH 7. 5 with 500 mM NaCl. Human Elastase is a 28. 5kDa serine protease that has been purfied from human neutrophils. Elastase is also present in the panceas leucocytes and serum
Function:	Modifies the functions of natural killer cells monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Catalytic Activity:	Hydrolysis of proteins including elastin. Preferential cleavage: Val-\|-Xaa & gt; Ala-\|-Xaa.
Subunit:	Interacts with NOTCH2NL.
Tissue Specificity:	Bone marrow cells.
Disease:	Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia affected individuals are at risk for opportunistic infection. Monocytes platelets lymphocytes and reticulocytes also cycle with the same frequency.
Disease:	Defects in ELA2 are the cause of autosomal dominant severe congenital neutropenia type 1 (SCN1) [MIM:202700]. Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0. 5 x 10(9)/l and early onset of severe bacterial infections.
Similarity:	Belongs to the peptidase S1 family. Elastase subfamily [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

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Menge: 0.1 mg

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Lieferung vsl. bis 11.09.2025

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