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MAGEA2 Antibody (N-term)

MAGEA2 Antibody (N-term)

ArtNr	ABC-AP6164a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAGEA2, MAGE2, MAGEA2A, Melanoma-associated antigen 2, MAGE-2 antigen, Cancer/testis antigen 12, CT12
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Primary Accession	P43356
Antigen Type	Synthetic Peptide
Application	WB, FC
Bio Background	MAGEA2 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci.
Bio References	Rogner, U.C., et al., Genomics 29(3):725-731 (1995). De Smet, C., et al., Immunogenetics 39(2):121-129 (1994). De Plaen, E., et al., Immunogenetics 40(5):360-369 (1994). van der Bruggen, P., et al., Science 254(5038):1643-1647 (1991).
Clonality	Polyclonal
Clone/Animal Names	RB2194
Gene ID	266740; 4101
Gene Name	MAGEA2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Anti-MAGEA2 Antibody (N-term) at 1:2000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 35 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	Overlay histogram showing Hela cells stained with AP6164a(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AP6164a, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(1583138) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG1 (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
Type image 2	FC
Dilution image 2	1:25
Other Accession	NP_005352
Isotype	Rabbit Ig
Calculated MW	35055
Antigen Region	81-108
Antigen Source	HUMAN
Target/Specificity	This MAGEA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the N-terminal region of human MAGEA2.
NCBI Accession	NP_005352.1; NP_705692.1; NP_786884.1; NP_786885.1

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ABC-AP6164a-datasheet.pdf

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Menge: 400 ul

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