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MMP15 Antibody (N-term)

MMP15 Antibody (N-term)

ArtNr	ABC-AP6199a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MMP15, Matrix metalloproteinase-15, Membrane-type matrix metalloproteinase 2, Membrane-type-2 matrix metalloproteinase, SMCP-2, MMP-15, MT2-MMP, MTMMP2, MT2MMP, 3424-, MT-MMP 2
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Primary Accession	P51511
Antigen Type	Synthetic Peptide
Application	WB, IHC-P, FC
Bio Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP15 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
Bio References	Jung, M., et al., Prostate 55(2):89-98 (2003). Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). d'Ortho, M.P., et al., Eur. J. Biochem. 250(3):751-757 (1997). Sato, H., et al., Genomics 39(3):412-413 (1997). Mattei, M.G., et al., Genomics 40(1):168-169 (1997).
Clonality	Polyclonal
Clone/Animal Names	RB2029
Gene ID	4324
Gene Name	MMP15
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	The anti-MMP15 N-term Antibody (Cat.#AP6199a) is used in Western blot to detect MMP15 in mouse brain tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human colon carcinoma with MMP15 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	Flow cytometric analysis of WiDr cells using MMP15 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	NP_002419
Isotype	Rabbit Ig
Calculated MW	75807
Antigen Region	165-194
Antigen Source	HUMAN
Target/Specificity	This MMP15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human MMP15.
NCBI Accession	NP_002419.1

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Menge: 400 ul

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