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MMP17 Antibody (Center)

MMP17 Antibody (Center)

ArtNr	ABC-AP6201a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MMP17, MT4MMP, Matrix metalloproteinase-17, Membrane-type matrix metalloproteinase 4, Membrane-type-4 matrix metalloproteinase, MMP-17, MT4-MMP, 3424-, MTMMP4, MT-MMP 4
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Primary Accession	Q9ULZ9
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP17 is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
Bio References	Jung, M., et al., Prostate 55(2):89-98 (2003). Itoh, Y., et al., J. Biol. Chem. 274(48):34260-34266 (1999). Wang, Y., et al., J. Biol. Chem. 274(46):33043-33049 (1999). Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999). Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Clonality	Polyclonal
Clone/Animal Names	RB2033/2034
Gene ID	4326
Gene Name	MMP17
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-MMP17 Antibody (Center) (Cat.#AP6201a) in NCI-H460 cell line lysates (35ug/lane). MMP17(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q9R0S3; NP_057239
Predicted	M
Isotype	Rabbit Ig
Calculated MW	66653
Antigen Region	391-420
Antigen Source	HUMAN
Target/Specificity	This MMP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human MMP17.
NCBI Accession	NP_057239.4

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