NRG3 Antibody (C-term)

Synthetic Peptide

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Polyclonal

10718

Affinity Purified Rabbit Polyclonal Antibody (Pab)

NRG3 Antibody (E703) (Cat. #AP6224b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NRG3 antibody detected the NRG3 protein (arrow).

1:1000

IHC-P

Rabbit IgG

688-717

This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.