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PARP1 Antibody (N-term)

PARP1 Antibody (N-term)

ArtNr	ABC-AP6373A
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PARP1, PARP-1, PPOL, ADPRT, NAD(+) ADP-ribosyltransferase 1, Poly [ADP-ribose] polymerase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, ARTD1, ADP-ribosyltransferase diphtheria toxin-like 1
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Primary Accession	P09874
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	PARP1 is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Bio References	Tao, Z., Biochemistry 47 (21), 5804-5813 (2008) Gao, R., Mol. Cancer Ther. 7 (5), 1246-1250 (2008) Schreiber, V., EMBO J. 11 (9), 3263-3269 (1992)
Clonality	Polyclonal
Clone/Animal Names	RB14153
Gene ID	142
Gene Name	PARP1 (HGNC:270)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of PARP1 (arrow) using rabbit polyclonal PARP1 Antibody (N-term)(Cat.#AP6373a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PARP1 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	PARP1 Antibody (N-term) (Cat.#AP6373a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PARP1 antibody detected the PARP1 protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	PARP1 Antibody (N-term) (Cat. #AP6373a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	P11103
Predicted	M
Isotype	Rabbit Ig
Calculated MW	113084
Antigen Region	183-214
Antigen Source	HUMAN
Target/Specificity	This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-214 amino acids from the N-terminal region of human PARP1.
NCBI Accession	NP_001609.2

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ABC-AP6373A-datasheet.pdf

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Menge: 400 ul

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Lieferung vsl. bis 06.11.2025

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