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PINK1 (PARK6) Antibody (N-term T133)

ArtNr ABC-AP6406A
Hersteller Abcepta
Menge 400 ul
Kategorie
Typ Antibody Primary
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen WB, IHC-P
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products PINK1, mitochondrial, Serine/threonine-protein kinase PINK1, BRPK, PTEN-induced putative kinase protein 1
Lieferbar
Primary Accession
Q9BXM7
Antigen Type
Synthetic Peptide
Application
IHC-P, WB
Bio Background
Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
Bio References
Rogaeva, E., et al. Arch. Neurol. 61 (12), 1898-1904 (2004)
Hatano, Y., et al. Ann. Neurol. 56 (3), 424-427 (2004)
Healy, D.G., et al. Ann. Neurol. 56 (3), 329-335 (2004)
Valente, E.M., et al. Science 304 (5674), 1158-1160 (2004)
Nakajima, A., et al. Cancer Lett. 201 (2), 195-201 (2003)
Unoki, M. and Nakamura, Y. Oncogene 20 (33), 4457-4465 (2001)
Clonality
Polyclonal
Clone/Animal Names
RB07381
Gene ID
65018
Gene Name
PINK1
Subtitle
Purified Rabbit Polyclonal Antibody (Pab)
Reactivity
H
Legend image 1
Anti-Park6 (PINK1) Antibody (N-term) at 1:1000 dilution + A549 whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 63 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1
WB
Dilution image 1
1:1000
Legend image 2
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2
IHC-P
Dilution image 2
1:50~100
Other Accession
NP_115785
Isotype
Rabbit Ig
Calculated MW
62769
Antigen Region
118-147
Antigen Source
HUMAN
Target/Specificity
This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).
NCBI Accession
NP_115785.1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 400 ul
Lieferbar: In stock
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