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AKT1 Antibody (C-term)

AKT1 Antibody (C-term)

ArtNr	ABC-AP7028B
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, PKB alpha
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Primary Accession	P31749
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Bio References	Liao, Y., et al., Int. J. Cancer 107(4):676-680 (2003). Powell, D.J., et al., Mol. Cell. Biol. 23(21):7794-7808 (2003). Debnath, J., et al., J. Cell Biol. 163(2):315-326 (2003). Li, G., et al., Oncogene 22(44):6891-6899 (2003). Liao, Y., et al., Mol. Cell. Biol. 23(19):6836-6848 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB3023-3024
Gene ID	207
Gene Name	AKT1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of hAKT1-D453 (Cat. #AP7028b) in Y79 cell line lysates (35ug/lane).AKT1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Western blot analysis of AKT1 (arrow) using rabbit polyclonal hAKT1-D453 (Cat. #AP7028b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AKT1 gene (Lane 2) (Origene Technologies).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	AKT1 Antibody (C-term) (Cat. #AP7028b) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the AKT1 antibody detected the AKT1 protein (arrow).
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	AKT1 Antibody (C-term) (Cat. #AP7028b) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 4	FC
Dilution image 4	1:10~50
Other Accession	P47196; P31750
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	55686
Antigen Region	438-468
Antigen Source	HUMAN
Target/Specificity	This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-468 amino acids from the C-terminal region of human AKT1.
NCBI Accession	NP_001014431.1; NP_001014432.1; NP_005154.2

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Menge: 400 ul

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