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AMPK gamma (PRKAG1) Antibody (Center)

AMPK gamma (PRKAG1) Antibody (Center)

ArtNr	ABC-AP7048c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PRKAG1, 5'-AMP-activated protein kinase subunit gamma-1, AMPKg, AMPK subunit gamma-1, AMPK gamma1
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Primary Accession	P54619
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Bio References	Minokoshi, Y., et al., Nature 428(6982):569-574 (2004). Hamilton, S.R., et al., FEBS Lett. 500(3):163-168 (2001). Zidovetzki, R., et al., AIDS Res. Hum. Retroviruses 14(10):825-833 (1998). Reinton, N., et al., Genomics 49(2):290-297 (1998). Stapleton, D., et al., FEBS Lett. 409(3):452-456 (1997).
Clonality	Polyclonal
Clone/Animal Names	RB3173
Gene ID	5571
Gene Name	PRKAG1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	The anti-PRKAG1 Pab (Cat. #AP7048c) is used in Western blot to detect PRKAG1 in mouse heart tissue lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	Formalin-fixed and paraffin-embedded human testis tissue reacted with PRKAG1 Antibody (Center) (Cat.#AP7048c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:50~100
Other Accession	Q09138; O54950; P58108; NP_997626
Predicted	B, Pig
Isotype	Rabbit Ig
Calculated MW	37579
Antigen Region	265-295
Antigen Source	HUMAN
Target/Specificity	This AMPK gamma (PRKAG1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 amino acids from the Central region of human AMPK gamma (PRKAG1).
NCBI Accession	NP_001193638.1; NP_001193639.1; NP_002724.1

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Menge: 400 ul

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