MAPK10 Antibody (N-term)

Synthetic Peptide

MAPK10 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.

Polyclonal

5602

Purified Rabbit Polyclonal Antibody (Pab)

MAPK10 Antibody (C21) (Cat.# AP7222a) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPK10 antibody detected the MAPK10 protein (arrow).

1:1000

IHC-P

Rabbit IgG

7-34

This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human MAPK10.