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STK11 (LKB1) Antibody (N-term I29)

STK11 (LKB1) Antibody (N-term I29)

ArtNr	ABC-AP7239A
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	STK11, LKB1, Serine/threonine-protein kinase STK11, PJS, Liver kinase B1, Renal carcinoma antigen NY-REN-19, hLKB1
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Primary Accession	Q15831
Antigen Type	Synthetic Peptide
Application	IF, FC, WB, IHC-P
Bio Background	STK11, is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.
Bio References	Mart, et al., J. Biotechnol. 115(1):23-34 (2005). Shaw, R.J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(10):3329-3335 (2004). Suzuki, A., et al., Biochem. Biophys. Res. Commun. 324(3):986-992 (2004). Hearle, N., et al., Genes Chromosomes Cancer 41(2):163-169 (2004). Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB3547
Gene ID	6794
Gene Name	STK11 (HGNC:11389)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Confocal immunofluorescent analysis of STK11 (LKB1) Antibody (N-term I29)(Cat#AP7239a) with ZR-75-1 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Western blot analysis of STK11 (arrow) using rabbit polyclonal STK11 Antibody (Cat.#AP7239a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the STK11 gene (Lane 2) (Origene Technologies).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	STK11 Antibody (I29) (Cat. #AP7239a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the STK11 antibody detected the STK11 protein (arrow).
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 4	IHC-P
Dilution image 4	1:50~100
Legend image 5	STK11 (LKB1) Antibody (N-term I29) (Cat. #AP7239a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 5	FC
Dilution image 5	1:10~50
Other Accession	Q91604; D4AE59; Q9WTK7; Q0GGW5
Predicted	C, M, Rat, X
Isotype	Rabbit Ig
Calculated MW	48636
Antigen Region	14-44
Antigen Source	HUMAN
Target/Specificity	This STK11 (LKB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human STK11 (LKB1).
NCBI Accession	NP_000446.1

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