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CD163 Antibody (N-term)

CD163 Antibody (N-term)

ArtNr	ABC-AP7330a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CD163, sCD163, M130, Hemoglobin scavenger receptor, Scavenger receptor cysteine-rich type 1 protein M130, Soluble CD163
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Primary Accession	Q86VB7
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Bio References	Buehler, P.W., Abraham, B. Blood 113 (11), 2578-2586 (2009) Fabriek, B.O., van Bruggen, R. Blood 113 (4), 887-892 (2009) Strauss, M. and Levy, A.P. Mol. Cell. Biochem. 317 (1-2), 131-135 (2008) Groselj-Grenc, M., Ihan, A. Mediators Inflamm. 2008, 202646 (2008)
Clonality	Polyclonal
Clone/Animal Names	RB18866
Gene ID	9332
Gene Name	CD163
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of CD163 antibody (N-term) (Cat.#AP7330a) in K562 cell line lysates (35ug/lane). CD163 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD163 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Isotype	Rabbit Ig
Calculated MW	125451
Antigen Region	245-274
Antigen Source	HUMAN
Target/Specificity	This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
NCBI Accession	NP_004235.4; NP_981961.2

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Menge: 400 ul

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