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TYR Antibody (Center)

TYR Antibody (Center)

ArtNr	ABC-AP7345c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Tyrosinase, TYR, LB24-AB, Monophenol monooxygenase, Tumor rejection antigen AB, SK29-AB
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Primary Accession	P14679
Antigen Type	Synthetic Peptide
Application	IHC-P, IF, WB
Bio Background	TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The protein has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this protein result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation.
Bio References	Ostankovitch, M. J. Immunol. 182 (8), 4830-4835 (2009) Chintamaneni, C.D. Proc. Natl. Acad. Sci. U.S.A. 88 (12), 5272-5276 (1991)
Clonality	Polyclonal
Clone/Animal Names	RB19154
Gene ID	7299
Gene Name	TYR
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Confocal immunofluorescent analysis of TYR Antibody (Center)(Cat#AP7345c) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Western blot analysis of Tyrosinase Antibody (Center) (Cat.#AP7345c) in A375, 293 cell line lysates (35ug/lane). Tyrosinase (arrow) was detected using the purified Pab.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	TYR Antibody (Center) (AP7345c)immunohistochemistry analysis in formalin fixed and paraffin embedded human melanoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TYR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Other Accession	P11344
Predicted	M
Isotype	Rabbit Ig
Calculated MW	60393
Antigen Region	176-205
Antigen Source	HUMAN
Target/Specificity	This TYR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the Central region of human TYR.
NCBI Accession	NP_000363.1

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