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TMPRSS2 Antibody (N-term)

TMPRSS2 Antibody (N-term)

ArtNr	ABC-AP7377a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TMPRSS2, PRSS10, Serine protease 10, Transmembrane protease serine 2 catalytic chain, Transmembrane protease serine 2, 3421-, Transmembrane protease serine 2 non-catalytic chain
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Primary Accession	O15393
Antigen Type	Synthetic Peptide
Application	WB, IHC-P, FC
Bio Background	TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. Its gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.
Bio References	Gopalan, A., Cancer Res. 69 (4), 1400-1406 (2009) Hofer, M.D., Cancer Res. 69 (2), 640-646 (2009)
Clonality	Polyclonal
Clone/Animal Names	RB18784
Gene ID	7113
Gene Name	TMPRSS2 (HGNC:11876)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	TMPRSS2 Antibody (N-term) (RB18784) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TMPRSS2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 1	IHC-P
Dilution image 1	1:50~100
Legend image 2	TMPRSS2 Antibody (N-term) (Cat. #AP7377a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Legend image 3	Western blot analysis of TMPRSS2 Antibody (N-term) (Cat. #AP7377a) in 293, NCI-H460 cell line lysates (35ug/lane). TMPRSS2 (arrow) was detected using the purified Pab.
Type image 3	WB
Dilution image 3	1:1000
Isotype	Rabbit Ig
Calculated MW	53859
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This TMPRSS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TMPRSS2.
NCBI Accession	NP_001128571.1; NP_005647.3

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Menge: 400 ul

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