CDK2 Antibody (T14)

ArtNr	ABC-AP7518d
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CDK2, p33 protein kinase, Cyclin-dependent kinase 2, Cell division protein kinase 2, CDKN2
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Primary Accession	P24941
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
Bio References	Moshinsky, D.J., et al., Biochem. Biophys. Res. Commun. 310(3):1026-1031 (2003). Chow, J.P., et al., J. Biol. Chem. 278(42):40815-40828 (2003). O'Nions, J., et al., Oncogene 22(46):7181-7191 (2003). Yun, J., et al., J. Biol. Chem. 278(38):36966-36972 (2003). Izumiya, Y., et al., J. Virol. 77(17):9652-9661 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB7918
Gene ID	1017
Gene Name	CDK2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Cdk2 Antibody (T14) (Cat. #AP7518d) western blot analysis in 293, Hela cell line lysates (35ug/lane).This demonstrates the hCdk2 antibody detected the hCdk2 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDK2 Antibody (T14) (Cat.#AP7518d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q80YP0; Q00526; P23437; Q63699; P97377; O55076; Q5E9Y0
Predicted	B, Ha, M, Rat, X
Isotype	Rabbit Ig
Calculated MW	33930
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human CDK2.
NCBI Accession	NP_001789.2; NP_439892.2

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