DYRK1A Antibody (Center)

Synthetic Peptide

DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.

Polyclonal

1859

Purified Rabbit Polyclonal Antibody (Pab)

Anti-DYRK1A Antibody (Center) at 1:2000 dilution + NIH/3T3 whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 86 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:2000

85584

HUMAN

NP_001387.2; NP_567824.1; NP_569120.1; NP_569122.1