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ALK Antibody (Center)

ALK Antibody (Center)

ArtNr	ABC-AP7600C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ALK, ALK tyrosine kinase receptor, CD246, Anaplastic lymphoma kinase
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Primary Accession	Q9UM73
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2; 5)(p23; q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Bio References	Morris, S.W., et al., Oncogene 14(18):2175-2188 (1997). Iwahara, T., et al., Oncogene 14(4):439-449 (1997). Morris, S.W., et al., Science 263(5151):1281-1284 (1994). Morris, S.W., et al., Oncogene 15, 2883-2883 (1997).
Clonality	Polyclonal
Clone/Animal Names	RB15425
Gene ID	238
Gene Name	ALK (HGNC:427)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of ALK(Center)(arrow) using rabbit polyclonal ALK(Center) Antibody (Cat.#AP7600c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALK (Center) gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human testis tissue reacted with ALK antibody (Center) (Cat.#AP7600c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Isotype	Rabbit Ig
Calculated MW	176442
Antigen Region	636-666
Antigen Source	HUMAN
Target/Specificity	This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-666 amino acids from the Central region of human ALK.
NCBI Accession	NP_004295.2

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