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ERBB2 Antibody(C-term Y1248)

ERBB2 Antibody(C-term Y1248)

ArtNr	ABC-AP7629d
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ERBB2, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, Tyrosine kinase-type cell surface receptor HER2, MLN 19, HER2, NEU, NGL, MLN19, Metastatic lymph node gene 19 protein, CD340
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Primary Accession	P04626
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.
Bio References	Ehsani, A., et al., Genomics 15(2):426-429 (1993). Yamamoto, T., et al., Nature 319(6050):230-234 (1986). Coussens, L., et al., Science 230(4730):1132-1139 (1985). Semba, K., et al., Proc. Natl. Acad. Sci. U.S.A. 82(19):6497-6501 (1985).
Clonality	Polyclonal
Clone/Animal Names	RB15814
Gene ID	2064
Gene Name	ERBB2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of ERBB2(arrow) using rabbit polyclonal ERBB2 Antibody (Y1248) (Cat.#AP7629d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ERBB2 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Anti-ERBB2 Antibody(C-term Y1248) at 1:1000 dilution + T47D whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 138 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with ERBB2 Antibody(C-term Y1248), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Other Accession	P06494; P70424
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	137910
Antigen Region	1227-1255
Antigen Source	HUMAN
Target/Specificity	This ERBB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1255 amino acids from the C-terminal region of human ERBB2.
NCBI Accession	NP_001005862.1; NP_004439.2

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