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RET Antibody (N-term C166)

RET Antibody (N-term C166)

ArtNr	ABC-AP7669a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RET, CDHF12, CDHR16, PTC, RET51, Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
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Primary Accession	P07949
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Bio References	Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88(11):5438-5443 (2003). McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88(10):4911-4916 (2003). D'Alessio, A., et al., Endocrinology 144(10):4298-4305 (2003). Soares, P., et al., Oncogene 22(29):4578-4580 (2003). Punales, M.K., et al., J. Clin. Endocrinol. Metab. 88(6):2644-2649 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB00705
Gene ID	5979
Gene Name	RET (HGNC:9967)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-Ret Pab (Cat. #AP7669a) in SKBR3 cell lysate. Ret (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	124319
Antigen Region	152-182
Antigen Source	HUMAN
Target/Specificity	This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-182 amino acids from the N-terminal region of human RET.
NCBI Accession	NP_065681.1; NP_066124.1

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Menge: 400 ul

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Lieferung vsl. bis 06.11.2025

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