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Activin A Receptor Type IB (ACVR1B) Antibody (N-term)

Activin A Receptor Type IB (ACVR1B) Antibody (N-term)

ArtNr	ABC-AP7801a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ACVR1B, ACVRLK4, ALK4, Activin receptor type-1B, Activin receptor type IB, Activin receptor-like kinase 4, Serine/threonine-protein kinase receptor R2, SKR2, ALK-4, ACTR-IB
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Primary Accession	P36896
Antigen Type	Synthetic Peptide
Application	WB, FC
Bio Background	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
Bio References	Harrison, C.A., et al., J. Biol. Chem. 278(23):21129-21135 (2003). Mukasa, C., et al., Endocrinology 144(4):1603-1611 (2003). Danila, D.C., et al., J. Clin. Endocrinol. Metab. 87(10):4741-4746 (2002). Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002). Roijer, E., et al., Mamm. Genome 9(3):266-268 (1998).
Clonality	Polyclonal
Clone/Animal Names	RB3740
Gene ID	91
Gene Name	ACVR1B
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Anti-Activin A Receptor Type IB (ACVR1B) Antibody (N-term) at 1:1000 dilution + Human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 55 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	All lanes : Anti-Activin A Receptor Type IB (ACVR1B) Antibody (N-term) at 1:1000 dilution Lane 1: Human brain lysate Lane 2: Human liver lysate Lane 3: Mouse brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 55 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	All lanes : Anti-Activin A Receptor Type IB (ACVR1B) Antibody (N-term) at 1:1000 dilution Lane 1: Human brain lysate Lane 2: Mouse brain lysate Lane 3: Rat brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 55 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	Overlay histogram showing Jurkat cells stained with AP7801a(green line). The cells were fixed with 2% paraformaldehyde and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed at 1/200 dilution for 40 min at Room temperature. Isotype control antibody (blue line) was rabbit IgG1 (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
Type image 4	FC
Dilution image 4	1:25
Other Accession	P80202
Predicted	Rat
Isotype	Rabbit Ig
Calculated MW	56807
Antigen Region	39-68
Antigen Source	HUMAN
Target/Specificity	This Activin A Receptor Type IB (ACVR1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human Activin A Receptor Type IB (ACVR1B).
NCBI Accession	NP_004293.1; NP_064732.3; NP_064733.3

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Menge: 400 ul

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