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ACVRL1 Antibody (C-term)

ACVRL1 Antibody (C-term)

ArtNr	ABC-AP7807b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ACVRL1, TGF-B superfamily receptor type I, ACVRLK1, ALK1, Serine/threonine-protein kinase receptor R3, Activin receptor-like kinase 1, ALK-1, SKR3, TSR-I
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Primary Accession	P37023
Antigen Type	Synthetic Peptide
Application	IHC-P, FC, WB
Bio Background	ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Bio References	Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Berg, J.N., et al., Am. J. Hum. Genet. 61(1):60-67 (1997). Johnson, D.W., et al., Nat. Genet. 13(2):189-195 (1996). ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993). Attisano, L., et al., Cell 75(4):671-680 (1993).
Clonality	Polyclonal
Clone/Animal Names	RB03737
Gene ID	94
Gene Name	ACVRL1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of hACVRL1-L489 (Cat.#AP7807b) in Jurkat(lane 1), HepG2(lane 2) cell line lysates (35ug/lane). ACVRL1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	ACVRL1 Antibody (C-term) (Cat.#AP7807b) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit Ig
Calculated MW	56124
Antigen Region	474-503
Antigen Source	HUMAN
Target/Specificity	This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 amino acids from the C-terminal region of human ACVRL1.
NCBI Accession	NP_000011.2; NP_001070869.1

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Menge: 400 ul

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