AGT Antibody (C-term)

Synthetic Peptide

AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in AGT gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in AGT gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Polyclonal

183

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-AGT Antibody (C-term) (Cat.#AP7854b) in HepG2 cell line lysates (35ug/lane). AGT (arrow) was detected using the purified Pab.

1:1000

IHC-P

Rabbit Ig

418-450

This AGT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-450 amino acids from the C-terminal region of human AGT.