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BUBR1 (BUB1B) Antibody (N-term)

BUBR1 (BUB1B) Antibody (N-term)

ArtNr	ABC-AP8059a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	BUB1B, BUBR1, MAD3L, SSK1, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MAD3/BUB1-related protein kinase, Mitotic checkpoint kinase MAD3L, Protein SSK1, hBUBR1
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Primary Accession	O60566
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	BUB1B, a member of the Ser/Thr protein kinase family, is a probable component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. It can interact with BUB3, CENP-F, CENP-E and mitosin, and can be localized to nuclear kinetochores. This protein is highly expressed in thymus and spleen. The CD1 domain directs kinetochore localization and binding to BUB3. The protein possesses a cyclin destruction box sequence, which targets protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase. Defects in BUB1B are associated with tumor formation.
Bio References	Cahill, D.P., et al., Genomics 58(2):181-187 (1999). Davenport, J.W., et al., Genomics 55(1):113-117 (1999). Chan, G.K., et al., J. Cell Biol. 143(1):49-63 (1998). Cahill, D.P., et al., Nature 392(6673):300-303 (1998). Taylor, S.S., et al., J. Cell Biol. 142(1):1-11 (1998).
Clonality	Polyclonal
Clone/Animal Names	RB03121-03122
Gene ID	701
Gene Name	BUB1B
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of BUB1B (arrow) using rabbit polyclonal BUB1B Antibody (N-term) (Cat.#AP8059a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BUB1B gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	119545
Antigen Region	3-33
Antigen Source	HUMAN
Target/Specificity	This BUBR1 (BUB1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human BUBR1 (BUB1B).
NCBI Accession	NP_001202.4

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Menge: 400 ul

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